Cover. A simplified scheme for folding of a Candida group I ribozyme to its catalytically active structure. Most secondary structures (cylinders, upper left) of the ribozyme are formed in Tris buffer. Upon addition of magnesium, the ribozyme RNA rapidly folds (ms-s) to a compact structure (upper right), which then undergoes a slower conformational searching (min) for native contacts to form the catalytically active structure (Native). For further information see the paper by Xiao et al. in this issue [Nucleic Acids Res. (2003) 31, 3901--3908].
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