Cover. Modelling of the human dihydropyrimidine amidohydrolase, an enzyme that is involved in degradation of several anti-cancer drugs, into the known E.coli dihydroorotase structure. Amino acid side chains coordinating the zinc ions are shown. The figure illustrates the paper by Gojkovic et al. in this issue [Nucleic Acids Res. (2003) 31, 1683--1692] and has been kindly provided by Dr T. Mueller from Biozentrum, University of Wuerzburg, Germany.
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