Specific inhibition of HIV-1 reverse transcriptase RNase H by nucleic acid hairpins. A library of mini hairpin oligonucleotides with well defined backbone (2',5'-RNA, RNA or DNA) and base composition is generated through diversity oriented nucleic acid synthesis. The hairpins interfere specifically with the function of the RNase H domain of HIV-1 reverse transcriptase (RT), without affecting the RT's polymerase activity. For further details see the paper by Hannoush et al. in this issue [Nucleic Acids Research 2004, 32, 6164-6175].
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