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Cover.
Two crystal structures of a short DNA fragment d(gcGA[G]1Agc) show that two base-intercalated duplexes are assembled to form a quadruplex at a high K+ concentration and that at a lower K+ concentration, the two quadruplexes are further assembled to form an octaplex, in which the eight G5 residues form a stacked double G-quartet in the central part. These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg), according to a double Greek-key motif. For further details see Kondo et al. in this issue [Nucleic Acids Res. (2004) 32, 2541-2549].
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