Cover: The search for new antibiotics requires chemical synthesis, microbiological tests, and X-ray crystallography of complexes containing targets and drugs. The illustration shows, in the background, a Petri dish for measuring antibiotic resistance in bacteria (or minimal inhibitory concentration). At the top left is a crystallization drop with small crystals. Below this is the chemical structure of the aminoglycoside antibiotic paromomycin centered on the area devoid of antibiotic growth. At the top right is a global view of the Thermus thermophilus 30S structure with paromomycin complexed to the decoding A-site in the presence of a messenger RNA fragment and cognate tRNA anticodon hairpin loop. [Coordinates are from Ogle,J.M., Brodersen,D.E., Clemons,W.M.,Jr, Tarry,M.J., Carter,A.P. and Ramakrishnan,V. (2001) Science, 292, 897].
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