Cover: Model of a double strand DNA bound to a Sulfolobus shibatae DNA topoisomerase VI subunit B homodimer (PDB code: 1MX0) complexed to an nonhydrolyzable ATP analog. See the paper by Gadelle et al. in this issue for the identification of a new inhibitor for this enzyme, radicicol: Nucleic Acids Research (2005), 33, 2310–2317.
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