Cover: Schematic representation of protein-induced DNA bending by type II restriction endonuclease EcoRV. A double stranded DNA molecule (yellow) is held under tension between two beads (blue) trapped in optical tweezers (red beams). Dimeric EcoRV restriction enzymes (green) in solution diffuse in search of the DNA recognition site. Upon specific binding, the DNA in the complex is bent, after which both strands are cleaved. Using this single-molecule method, induced-fit rates and DNA bend angles can be extracted. For further information see the paper by van den Broek et al. in this issue [Nucleic Acids Res. (2005), 33, 2676–2684]
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