Cover: Proposed mode of CcdB binding the gyrase. Crystal structure of the N-terminal domain of GyrA (left) and the proposed complex with the protein toxin CcdB (1,2). See the paper by Smith and Maxwell (2006), Nucleic Acids Res., 34, 4667–4676.
1. Loris, R., Dao-Thi, M.-H., Bahassi, E.M., Van Melderen, L.V., Poortmans, F., Liddington, R.C., Couturier, M. and Wyns, L.(1999) Crystal structure of CcdB, a topoisomerase poison from E. coli. J. Mol. Biol., 285, 1667–1677.
2. Dao-Thi, M.H., Van Melderen, L., De Genst, E., Afif, H., Buts, L., Wyns, L. and Loris, R. (2005) Molecular basis of gyrase poisoning by the addiction toxin CcdB. J Mol Biol, 348, 1091–1102.
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