Cover: A docking model of the two domains from the archaeal m22G10 methyltransferase onto its tRNAAsp substrate. The methylation target G10 (cyan), the conserved G53-C61 pair (magenta), the T-arm (yellow), and the acceptor stem (violet) of the tRNA (backbone as a white tube) are shown. The models of the N-terminal THUMP domain (blue to green) and the C-terminal catalytic domain (yellow to red) of the methyltransferase are shown in the cartoon representation. The AdoMet molecule is shown in white. See Gabant et al. (2006) Nucleic Acids Res., 34, 2483–2494.
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