Cover: Base flipping in Tn5 transposition. Strand separation provides the steric freedom required for the processing of DNA-hairpin intermediates in recombination reactions. In the transposon Tn5, the base at position +2 of the nontransferred strand (green) is .ipped form the helix and stacked against a tryptophan residue (blue). A second tryptophan residue (blue) enters the helix, disrupting base pairing and stacking. An active site manganese is highlighted in magenta. See the paper by Bischerour and Chalmers (2007), Nucleic Acids Res., 35, 2584-2595.
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