Cover: Visual presentation of knot distance metric created using the software TopoICE-X within KnotPlot. A pair of knots in this graph is connected by an edge if they can be converted into one another via a single intersegmental passage such as DNA-DNA passages mediated by type II DNA topoisomerases acting on knotted circular DNA molecules. This graph shows all mathematically possible topoisomerase reaction pathways involving small crossing knots. For further details, see the article by Darcy et al. (Nucleic Acids Res., 2008; 36: 3515–3521).
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