Cover: Inhibition of DNA-promoted amyloidogenesis by small molecules. RIGHT ARROW: dsDNA molecules (green) transiently bind to the dimeric WH1 domain of pPS10 plasmid protein RepA (ribbon: α-helices in cyan, β-strands in magenta). DNA phosphates neutralize a cluster of basic residues in WH1 (blue spheres), thus chaperoning fiber assembly (background micrograph). LEFT ARROW: S4-indigo (spheres), competing with dsDNA binding to RepA-WH1, inhibits amyloid assembly.
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